Drug Discovery

Our proven approach to drug discovery emphasizing small-molecule drugs assigns a crucial role to the close interaction between synthetic organic chemistry, pharmacology and drug delivery. Aderis scientists believe that it's critically important to understand what chemical and pharmacological properties are required to create a drug. Successful drugs should be efficiently synthesized on a large scale, easily characterized, stable and allow simple product and dosage formulation for the intended application. Further, the pharmacological properties should include receptor subtype selectivity, high potency, excellent safety and toxicological profile as well as an appropriate duration of action.

Our drug discovery process involves a series of iterations between chemical synthesis and pharmacological testing in order to rapidly identify and optimize lead molecules. Using efficient, highly specific assays, we can quickly determine a compound's affinity for the targeted receptor subtype as well as its functional activity in tissues. Then we use synthetic chemistry to modify the molecule to introduce features that confer desirable properties such as bioavailability. Our goal is to design and synthesize potent, receptor-subtype-selective small molecules that are defined by the qualities required for straightforward product formulation and efficient large scale manufacturing.

Our scientists' extensive expertise has allowed us to diversify our structural approach, rapidly identify structural features required for specific pharmacological activity and apply medicinal chemistry to refine our lead compounds.

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